The Hephaestion was an Excelsior-class starship first launched in 2343 which served in Starfleet until her destruction in 2399. During this fifty-year career, the Hephaestion served with distinction in the Federation-Cardassian War and the Dominion War, but was primarily a ship of exploration. Although decommissioned in 2386, then-Rear Admiral Jonathan Knox had her put back to service in 2393 as his flagship.
For views of her interior, check out Tadeo D’Oria’s awesome renders of the Potemkin, one of the Hephaestion’s sister ships:
Main Bridge | Captain’s Ready Room | Observation Lounge | Briefing Room
Main Engineering | Sickbay | Battle Bridge | Aft Shuttlebay
2358-2371 – Captain Renatta Thompson
2371-2386 – Captain Jonathan Knox
2386-2393 – Out of Commission
2393-2399 – Captain Raoul Fontaine